From Frankfurt: Autobahn A5 Frankfurt-Basel;
From Stuttgart: On the A8 Munich-Karlsruhe freeway, at the Karlsruhe junction take the A5 towards Frankfurt;
From there:
At exit no. 44 Karlsruhe-Durlach, take the B10 in the direction of Karlsruhe, follow Durlacher Allee in the direction of Stadtmitte, turn right at the 2nd traffic light intersection immediately after the railroad underpass, follow the Ostring in the direction of Hauptfriedhof, then turn left into Haid-und-Neu-Straße, then take the second street on the right (Stumpfstraße) until you reach Fraunhoferstraße